Wile E. Coyote is a member of the Looney Tunes. He is mostly a villain, always trying to catch and eat The Road Runner , but he sometimes help the other Looney Tunes. He appeared in "Who Framed Roger Rabbit" as a resident of Toontown and a friend of Eddie Valiant and Roger Rabbit.

He appeared in "Space Jam" as a member of the basketball team that the Looney Tunes put together to defeat the Monstars. He appeared in "Looney Tunes: Back in Action" as a henchman working for Doctor Acme . After failing to kill Bugs Daffy , DJ Drake and Kate Houghton , Doctor Acme tries to kill him for his failure, but his immortality makes him impossible to be killed by Doctor Acme, thus he survives the whole movie. Calamity Coyote is his nephew.

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